张明真

程研究所副所长。华中科技大学博士； 美国佐治亚州立大学博士后、
助理教授； 西安交通大学医学部基础医学院特聘研究员。主要从事
结肠炎及结肠癌的精准诊疗研究， 涉及新型纳米递送系统、 诊疗一
申请发明专利 6 项。主持/参与国家自然科学基金、美国 CCFA 基金会基金、科技部重点研
发计划、陕西省自然科学基金，国家卫健委胃肠肿瘤诊治重点实验室开放基金等项目 10 余
项， 入选陕西省普通高校“青年杰出人才支持计划”、西安交通大学“青年拔尖人才计划”及西
安交通大学医学部“国家级后备人才支持计划”等。多次受邀作为 Advanced Functional
Materials, ACS Nano, Biomaterials 等权威杂志审稿人。现为 Frontiers inDrug Delivery 副主编，
Frontiers in Molecular Biosciences、 Catalysts 杂志客座编辑。 Frontiers in Materials, Frontiers in
Bioengineering andBiotechnology 评审编辑、 Chinese Chemical Letters 青年编委， 右江医学青
年编委， Journal ofClinical andTranslational Research 编委。陕西省抗癌协会整合肿瘤免疫治
疗分会常委， 陕西省纳米科技学会理事会理事， 中国生物材料学会会员， 中国医学工程学会 会员，生物物理学会会员，中国微米纳米技术学会高级会员。

研究领域及方向 1：
以炎症性肠道疾病（IBD） 和结肠癌为主要研究目标， 围绕疾病诊断、治疗及致病分子
机理，开展以下工作：
药物靶向递送。
结肠癌声动力治疗。
生物标记物检测与传感。

研究领域及方向 2：
碳基纳米酶性质、机理及应用开发。

申请专利：
1. 张明真， 颜湘冀， 杨梅， 马雅娜， 方碧云； 一种姜黄衍生的类外泌体纳米颗粒及其制备 方法；申请号： CN202010124686.0。 （第一申请人）
2. Didier Merlin, Mingzhen Zhang; Compositions and methods based on plant-derived nanoparticles; 申请号： 62/438,948。（第二申请人）
3. 戴正飞， 梁婷婷， 张明真， 刘耀达； 一种非晶硼酸钴-单硒化镍@泡沫镍的复合物、制备 方法及应用；专利号： ZL2020105010005。（第三申请人）


4. 张明真，刘翠，高文慧，张保军；一种 Pt-CDs 复合纳米材料以及制备方法；申请号： 202110442769.9； 申请号： 202110442769.9 （第一申请人）
5. 张明真， 方碧云， 贾真真， 张保军； 一种基于个人血糖仪读数的核酸即时检测方法及其 试剂盒；申请号： 2021111228613 （第一申请人）
6. 刘翠， 张明真， 高文慧， 庞代文， 涂康生； 一种具有超氧化物歧化酶活性碳点的制备方 法及其催化用途；申请号： 202111289705.6 （第二申请人）
7. 张明真；韦伟； 方碧云； 贾真真； 一种基于妊娠试纸的溶菌酶即时检测方法及其试剂盒；


学术任职：
1. 西安交通大学基础医学院青年学者委员会副主任委员
2. 右江医学杂志青年编委
3. Frontiers in Molecular Biosciences 杂志客座编辑
4. 陕西省抗癌协会整合肿瘤免疫治疗分会常委
5. 陕西省纳米科技学会理事会理事
6. Chinese Chemical Letters 青年编委
7. Journal of Clinical and Translational Research 编委

代表性论文：
2022 年
1. Yang M, Yang CH, Zhang YJ, Yan XJ, Ma YN, Zhang YY, Cao YM, Xu QR*, Tu KS* and
Zhang MZ*. Orally pH-activated "nano-bomb" carrier combined with berberine by regulating
gene silencing and gut microbiota for site-specific treatment ofulcerative colitis. Biomaterials
Science. 2022, 10(4):1053-1067. (IF=6.84)
2. Ma YN, Gao WH, Zhang YJ, Yang M, Yang XJ, Zhang YY, Li GY, Liu C*, Xu CL* and Zhang
MZ*. Biomimetic MOF nanoparticles delivery ofC-dot nanozyme and CRISPR/Cas9 system
for sitespecific treatment of ulcerative colitis. ACS Applied Materials & Interfaces. 2022,
14(5), 6358−6369. (IF=9.229)
3. Gong LY, Zhang YJ, Zhang YL, Tu KS, Jiao LY, Xu QR, Zhang MZ*and Han SX*. All-in-
one Biomimetic Nanoplatform Based on Hollow Polydopamine Nanoparticles for
Synergistically Enhanced Radiotherapy of Colon Cancer. Small. 2022, e2107656. (IF=13.28)
4. Yan XJ, Yang CH, Yang M, Ma YN, Zhang YY, Zhang YJ, Liu C, Xu QR*, Tu KS* and Zhang
MZ*. All-in-one theranostic nano-platform based on polymer nanoparticles for BRET/FRET-
initiated bioluminescence imaging and synergistically anti-inflammatory therapy for ulcerative
colitis. Journal of Nanobiotechnology. 2022, 20(1): 99. (IF=10.435)

5. Liu C#, Yan XJ#, Zhang YJ#, Yang M, Ma YN, Zhang YY, Xu QR*, Tu KS* and Zhang MZ*.
Turmeric-derived exosome-like nanovesicles with anti-inflammatory and pro-resolving
bioactions for treatment of ulcerative colitis. Journal of Nanobiotechnology. 2022.
(IF=10.435)
6. Wei W, Zhang YJ, Li RQ, Cao YM, Yan XJ, Ma YN, Zhang YY, Yang M* and Zhang MZ*.
Oral delivery of pterostilbene by L-Arginine-mediated “nano-bomb” carrier for the treatment
ofulcerative colitis. International Journal of Nanomedicine. 2022, 17, 603-616. (IF=6.4)
7. Liu C, Wei XX, Zhang MZ, Hildebrandt N, Luo QY* and Jin ZW*. Nucleic Acid
Hybridization Enhanced Luminescence for Rapid and Sensitive RNA and DNA Based
Diagnostics (In submission).
8. Xu JW#*, Yan XJ#*, Zhang Y, Tu KS, Shen W, Tian ZQ, Zhao W* and Zhang MZ. Tunable
paclitaxel release carrier using diselenide-disulfide balance as regulator. Journal of Industrial
and Engineering Chemistry. 2022. (IF: 6.0644)
9. Yan XJ, Zhang XZ, Zhang YJ, Yang M, Ma YN, Zhang YY, Xu QR*, Tu KS* andZhang MZ*.
Reactive Oxygen Species-responsive Nanocarrier Ameliorates Ulcerative Colitis by
Regulating Colonic M1/M2 Macrophage Polarization and CD4+ T Cell Infiltration. Journal of
Crohn's and Colitis (Under review)
10. Gao WH#, Zhang YJ#, Ma YN, Cheng LL, Zhang MX*, Liu C*, and Zhang MZ*. Pt@Carbon
Nanodots composite with cascade superoxide dismutasecatalase activity for versatile reactive
oxygen species scavenging. Angewandte Chemie. (In submission).
11. Gao WH, He JY, Chen L, Meng XQ, Ma YN, Liu C*, Zhang MZ*, Fan KL*, Pang D-W* and
Yan XY*. Deciphering the catalytic mechanism of superior superoxide dismutase activity of
carbon dot nanozyme. Nature Catalysis. (In submission).

2021 年
1. Gong LY, Zhang YJ, Liu CC, Zhang MZ* and Han SX*. Application of Radiosensitizers in
Cancer Radiotherapy. International Journal ofNanomedicine. 2021; 16: 1083-1102. (IF=6.4)

2.

3.


4.



5.


颜湘冀，张玉洁， 张明真*。中性粒细胞在溃疡性结肠炎中的作用机制及靶向治疗策略
[J]. 右江医学, 2021; 49(2): 87-91
Jia ZZ, Tu KS, Xu QR, Gao WH, Liu C, Fang BY* and Zhang MZ*. A novel disease-
associated nucleic acid sensing platform based on split DNA-scaffolded sliver nanocluster.
Analytica Chimica Acta. 2021. (IF=6.558)
Wang XY#, Zhang MZ#, Woloshun R, Yu Y, Lee J, Flores S, Merlin D and Collins J. Oral
Administration ofGinger-Derived Lipid Nanoparticles and Dmt1 siRNApotentiates the Effect
of Dietary Iron Restriction and Mitigates Pre-Existing Iron Overload in Hamp KO Mice.
Nutrients. 2021, 13(5), 1686. (IF=5.717)
Fang BY*, Jia ZZ, Liu C, Tu KS, Xu QR* and Zhang MZ. Aversatile CRISPR Cas12a-based




point-of-care biosensor enabling convenient glucometer readout for ultrasensitive detection of
pathogen nucleic acids. (Under review)


6.

7.


8.



Ma YN, Qu XL, Liu C, Xu QR* and Tu KS*. Metal-organic frameworks and their composites
towards bio-medical applications. Front. Mol. Biosci. 2021, 8: 805228.
Zhou Y, Yan XJ, Yang M, Ma YN, Zhang YY, Zhang YJ, Zhang MX* and Zhang MZ*. Oral
delivery of therapeutic rographolide/carbon monoxide (CO) donor for synergistic treatment of
ulcerative colitis by anti-inflammation and pro-resolution. (In preparation)
Therapeutic Albumin Nanoparticles Hitchhike Activated Neutrophil Across Vascular Barrier
for Subcutaneous and Orthotopic Colon Cancer Therapy (In submission)


2020 年
1. An J, Hu YG, Chang K, Li C, Hou XL, Wang GL, Zhang XS, Liu B, Zhao YD* and Zhang
MZ*. ROS-Augmented and Tumor-Microenvironment Responsive Biodegradable
Nanoplatform for Enhancing Chemo-Sonodynamic Therapy. Biomaterials. 2020; 234: 119761.
(IF=12.479)
2. Fang BY*, Guo P, Yang M, Ma YN, Yan XJ, Jia ZZ, Gao WH, Ahmad S, Xu CL, Liu C and
Zhang MZ*. A Novel Fluorescent Enhancing Platform Based on DNA-scaffolded Silver
Nanoclusters for Potential Inflammatory Bowel Disease-associated MicroRNA Detection.
Talanta. 2020; 218: 121122. (IF=6.057)
3. Yang CH, Zhang MZ, Lama S, Wang LX and Merlin D. Natural-lipid nanoparticle-based
therapeutic approach to deliver 6-shogaol and its metabolites M2 and M13 to the colon to treat
ulcerative colitis. Journal of Controlled Release. 2020; 323: 293-310. (IF=9.776)
4. Yang CH, Zhang MZ, Sung J, Wang LX, Jung Y and Merlin D. Isolation and Characterization
ofExosomes from Mouse Feces. Bio-protocol. 2020; 10(8): e3584.
5. Shi Q, Cheng YH, Dong XM, Zhang M, Pei C and Zhang MZ*. Effects of rhaponticin on
retinal oxidative stress and inflammation in diabetes through NRF2/HO-1/NF-kB signaling.
Journal ofBiochemical and Molecular Toxicology. 2020; e22568. (IF=3.642)
6. Yang M, Zhang YJ, Ma YN, Yan XJ, Gong LY, Zhang MZ* and Zhang BJ*. Nanoparticle-
based therapeutics of inflammatory bowel diseases: the current state and prospects. Journal of
Bio-X Research (2020) 3(4):157–173.
7. Liu C*, Zhang F, Hu J and Zhang MZ. A mini review on pH-sensitive photoluminescence in
carbon nanodots. Frontiers in Chemistry. 2020; 8: 1242. (IF=5.221)
8. Xu Jingwen*, Yan Xiangji, Ge Xin, Zhang MZ, Dang Xugang, Yang Yan, Xu Feng*, Luo
Yanling and GuoLiang Li. Novel multi-stimuli responsive functionalized PEG-based co-
delivery nanovehicles toward sustainable treatments of multidrug resistant tumor. Journal of
Materials Chemistry B. 2021; 9, 1297-1314. (IF=6.331)

2019 年
1. Zhang MZ*, Yang CH, Yan XJ, Sung JK, Garg P and Merlin D. Highly Biocompatible
Functionalized Layer-by-Layer Ginger Lipid Nano Vectors Targeting P-Selectin for Delivery
ofDoxorubicin to Treat Colon Cancer. Advanced Therapeutics. 2019; 2: 1900129. (Wiley new

journal)
2. Yang M, Zhang F, Yang C, Wang L, Sung J, Garg P, Zhang MZ* and Merlin, D. Oral targeted
delivery by nanoparticles enhances efficacy of an Hsp90 inhibitor by reducing systemic
exposure in murine models of colitis and colitis-associated cancer. Journal of Crohn's and
Colitis. 2020; 14(1):130-141. (IF=9.071)
3. Wang X, Zhang MZ, Flores SR, Woloshun RR, Yang C, Yin L, Xiang P, Xu X, Garrick MD,
Vidyasagar S, Merlin D and Collins JF*. Oral Gavage of Ginger Nanoparticle-Derived Lipid
Vectors Carrying Dmt1 siRNA Blunts Iron Loading in Murine Hereditary Hemochromatosis.
Molecular Therapy. 2019; 27(3):493-506. (IF=11.454)
4. Li C, Yang XQ, Zhang MZ, Song YY, Cheng K, An J, Zhang XS, Xuan Y, Liu B, Zhao YD.
In vivo Imaging-Guided Nanoplatform for Tumor Targeting Delivery and Combined Chemo-,
Gene-and Photothermal Therapy. Theranostics. 2018; 8(20):5662. (IF=11.556)
5. Yang C, Zhang MZ, Sung J, Wang L, Jung Y and Merlin D. Autologous Exosome Transfer: A
New Personalized Treatment Concept to Prevent Colitis in a Murine Model. Journal ofCrohn's
and Colitis. 2019. (IF=9.071)



2018 年之前
1. Zhang MZ*, Xu CL, Wen LQ, Han MK, Xiao B, Zhou J and Merlin D. A hyaluronidase
responsive nanoparticle-based drug delivery system for targeting colon cancer cells. Cancer
Research. 2016; 76(24), 7208-7218. (IF=12.701)
2. Zhang MZ*, Viennois E, Prasad M, Zhang YC, Wang LX, Zhang Z and Merlin D. Edible
ginger-derived nanoparticles: a novel therapeutic approach for the prevention and treatment of
inflammatory bowel disease and colitis-associated cancer. Biomaterials. 2016; 101:321-340.
(IF=12.479)
3. Zhang MZ, Yu Y, Yu RN, Wan M, Zhang RY and Zhao YD*. Tracking the down-regulation of
folate receptor-α in cancer cells through target specific delivery of quantum dots coupled with
antisense oligonucleotide and targeted peptide. Small. 2013; 9:4183-4193. (IF=13.281)
4. Zhang MZ*, Xiao B, Wang H, Han MK, Zhang Z, Viennois E and Merlin D. Edible ginger-
derived nano-lipids loaded with doxorubicin as a novel drug-delivery approach for colon
cancer therapy. Molecular Therapy. 2016; 24(10):1783-96. (IF= 11.454)
5. Zhang MZ*, Xu CL, Liu DD, Han MK, Wang LX and Merlin D. Oral delivery ofnanoparticles
loaded with ginger active compound, 6-shogaol, attenuates ulcerative colitis and promotes
wound healing in a murine model of ulcerative colitis. Journal of Crohn’s and Colitis. 2018;

12(2): 217-229. (IF=9.071)
6. Zhang MZ*, Viennois E, Xu CL and Merlin D. Plant derived edible nanoparticles as a new
therapeutic approach against diseases. Tissue Barriers. 2016; e1134415.
7. Zhang MZ*, Collins JF and Merlin D. Do Ginger-derived nanoparticles present an attractive
treatment strategy for inflammatory bowel disease? Nanomedicine. 2016; 3035-3037.
(IF=5.307)
8. Zhang MZ*, Wang XY, Han MK, Collins JF and Merlin D. Oral administration of ginger-
derived nano-lipids loaded with siRNA as a novel approach for efficient siRNA drug delivery
to treat ulcerative colitis. Nanomedicine. 2017; 12(16), 1927-1943. (IF=5.307)
9. Zhang MZ, Yu RN, Chen J, Ma ZY and Zhao YD*. Targeted quantum dots fluorescence
probes functionalized with aptamer and peptide for transferrin receptor on tumor cells.
Nanotechnology. 2012; 23:485104. (IF=3.874)
10. Zhang MZ, Li C, Fang BY, Yao MH, Ren QQ, Zhang L and Zhao YD*. High transfection
efficiency of quantum dot-antisense oligonucleotide nanoparticles in cancer cells through dual-
receptor synergistic targeting. Nanotechnology. 2014; 25:255102. (IF=3.874)
11. Zhang MZ* and Merlin D. Nanoparticle-Based Oral Drug Delivery Systems Targeting the
Colon for Treatment of Ulcerative Colitis. Inflammatory Bowel Diseases. 2018; 24(7):1401-
1415. (IF=5.325)
12. Wen L, Jiang K, Zheng Y, Zhang MZ, Kondengaden SM, Li S, Wang GP*. Two-step chemoenzymatic detecting N-Acetylneuraminic acid-α (2-3)-galactose glycans. Journal of the American Chemical Society. 2016;138 (36):11473–11476. (Impact factor: 13.858)
13. Xiao B*, Zhang Z, Viennois E, Kang YJ, Zhang MZ, Han MK, et al. Combination therapy for ulcerative colitis: orally targeted nanoparticles prevent mucosal damage and relieve inflammation. Theranostics. 2016;6(12):2250-2266. (Impact factor: 8.712)
14. Xiao B*, Zhang MZ, Viennois E, Zhang Y, Wei N, Baker MT, et al. Inhibition ofMDR1 gene expression and enhancing cellular uptake for effective colon cancer treatment using dual- surface-functionalized nanoparticles. Biomaterials. 2015;48:147-160. (Impact factor: 8.402)
15. Xiao B*, Han MK, Viennois E, Wang L, Zhang MZ, Si X, et al. Hyaluronic acid- functionalized polymeric nanoparticles for colon cancer-targeted combination chemotherapy. Nanoscale. 2015;7:17745-17755. (Impact factor: 7.367)
16. Yang J, Yao MH, Wen L, Song JT, Zhang MZ, Zhao YD*, Liu B*. Multifunctional quantum dot–polypeptide hybrid nanogel for targeted imaging and drug delivery. Nanoscale. 2014;6:11282-11292. (Impact factor: 7.367)
17. Zhou ZM, Zhou J, Chen J, Yu RN, Zhang MZ, Song JT, Zhao YD*. Carcino-embryonic antigen detection based on fluorescence resonance energy transfer between quantum dots and graphene oxide. Biosensors ＆ Bioelectronics. 2014;59:397-403. (Impact factor: 7.78)
18. Viennois E*, Ingersoll SA, Ayyadurai S, Zhao Y, Wang L, Zhang MZ, et al. Critical role of PepT1 in promoting colitis-associated cancer and therapeutic benefits of the anti-inflammatory

PepT1-mediated tripeptide KPV in a murine model. Cellular and Molecular Gastroenterology and Hepatology. 2016; 2:340-357. (Newjournal)
19. Xiao B*, Si X, Han MK, Viennois E, Zhang MZ, Merlin D. Co-delivery ofcamptothecin and curcumin by cationic polymeric nanoparticles for synergistic colon cancer combination chemotherapy. Journal ofMaterials Chemistry B. 2015;3:7724-7733. (Impact factor: 4.543)
20. Xia HX, Yang XQ, Song JT, Chen J, Zhang MZ, Yan DM, Zhao YD*. Folic acid-conjugated silica-coated gold nanorods and quantum dots for dual-modality CT and fluorescence imaging and photothermal therapy. Journal of Materials Chemistry B. 2014;2:1945-1953. (Impact factor: 4.543)
21. Guan LY, Li YQ, Lin S, Zhang MZ, Chen J, Ma ZY, Zhao YD*. Characterization of CdTe/CdSe quantum dots-transferrin fluorescent probes for cellular labeling. Anal Chim Acta. 2012;741:86-92. (Impact factor: 4.95)
22. Xiao B*, Si X, Zhang MZ, Merlin D. Oral administration of pH-sensitive curcumin-loaded microparticles for ulcerative colitis therapy. Colloids and Surfaces B: Biointerfaces. 2015;135:379-385. (Impact factor: 3.887)
23. Zhang HL, Li YQ, Zhang MZ, Zhao YD*. Real-time observation of the effect of iron on receptor-mediated endocytosis of transferrin conjugated with quantum dots. Journal of Biomedical Optics. 2010;15:045003-045006. (Impact factor: 2.53)
24. Huang HH, Chen J, Meng YZ, Yang XQ, Zhang MZ, Yu Y, Zhao YD*. Synthesis and characterization of Bi2S3 composite nanoparticles with high X-ray absorption. Materials Research Bulletin. 2013;48:3800-3804. (Impact factor: 2.446)
25. Zhang HL#, Zhang MZ#, Li XY, Wan M, Li YQ, Zhang RY, Zhao YD*. A convenient method of preparing gene vector for real time monitoring transfection process based on the quantum dots. Materials Research Bulletin. 2012;47:3330-3335. (Impact factor: 2.446)
26. Wen W, Bao T, Yang J, Zhang MZ, Chen W, Xiong HY, Zhao YD*. A novel amperometric adenosine triphosphate biosensor by immobilizing graphene/dual-labeled aptamers complex onto poly (o-phenylenediamine) modified electrode. Sensors and Actuators B: Chemical. 2014;191:695-702. (Impact factor: 5.401)
27. Yu Y, Zhang MZ, Chen J, Zhao YD*. Homogeneous synthesis ofSiO2@TiO2 nanocomposites with controllable shell thickness and their enhanced photocatalytic activity. Dalton Transactions. 2013;42:885-889. (Impact factor: 4.029)
28. Zhou ZM, Yu Y, Zhang MZ, Chen J, Ren QQ, Song JT, Zhao YD*. Chemiluminescence detection of lead (II) using ‘8–17’ DNAzyme and hemin/G-quadruplex with high sensitivity and selectivity. Sensors and Actuators B: Chemical. 2014;201:496-502. (Impact factor: 5.401)
29. Xiao B*, Xu ZG, Viennois E, Zhang YC, Zhang Z, Zhang MZ, Han MK, Kang YJ, Merlin D. Orally Targeted Delivery ofTripeptide KPV via Hyaluronic Acid-functionalized Nanoparticles



Efficiently Alleviates Ulcerative Colitis. Molecular Therapy. 2016; 25(7):1628-40. (Impact factor: 6.688)
30. Yang CH*, Zhang MZ, Merlin D. Advances in Plant-derived Edible Nanoparticles-based lipid Nano-drug Delivery Systems as Therapeutic Nanomedicines. Journal of Materials Chemistry B. 2018; 6:1312-1321. (Impact factor: 4.543)
31. Sung J, Yang C, Viennois E, Zhang MZ, Merlin D. Isolation, Purification, and Characterization ofGinger-derived Nanoparticles (GDNPs) from Ginger, Rhizome ofZingiber officinale. Bio Protoc. 2019;9(19):e3390.
32. Han MK, Baker M, Zhang Y, Yang C, Zhang MZ, Garg P, Viennois E, Merlin D.
Overexpression of CD98 in intestinal epithelium dysregulates miRNAs and their targeted
proteins along the ileal villus-crypt axis. Scientific reports. 2018;8(1):1-16.
33. Viennois E*, Zhao Y, Han MK, Xiao B, Zhang MZ, Prasad M, Wang L, Merlin D. Serum miRNA signature diagnoses and discriminates murine colitis subtypes and predicts ulcerative colitis in humans. Scientific Reports. 2017;7:2520. (Impact factor: 4.259)
34. Zhang Y*, Viennois E, Zhang MZ, Xiao B, Han MK, Walter L, et al. PepT1 expression helps maintain intestinal homeostasis by mediating the differential expression ofmiRNAs along the crypt-villus axis. Scientific Reports. 2016;6:27119. (Impact factor: 4.259)
35. Chen GW, Zhang MZ, Zhao LF, Xu CS*. Expression patterns and action analysis of genes associated with physiological responses during rat liver regeneration: Innate immune response.
World Journal of Gastroenterology. 2006;12:7852-7858. (Impact factor: 3.365)
会议论文：
1. Zhang MZ*, Viennois E, Merlin D. Tu1876 Ginger derived nanoparticles: a novel therapeutic approach for the treatment ofIBD. Gastroenterology. 2016;150:S966. (Impact factor: 18.392)
2. Zhang MZ*, Viennois E, Merlin D. P-139 YI Ginger derived nanoparticles: a novel therapeutic approach for the treatment of IBD. Inflammatory Bowel Disease. 2016;22:S52- S53. (Impact factor: 4.525)
3. Xiao B*, Viennois E, Zhao Y, Zhang Y, Jung Y, Zhang MZ, et al. Mo1204 inhibition ofMDR1 gene expression and enhancing cellular uptake for effective colon cancer treatment using dual- surface-functionalized nanoparticles. Gastroenterology. 2015;148:S638. (Impact factor: 18.392)
4. Viennois E*, Zhao Y, Zhang MZ, Han M, Merlin D. O-016 YI Longitudinal study of circulating miRNAbiomarkers in inflammatory bowel disease. Inflammatory Bowel Diseases. 2016;22:S6. (Impact factor: 4.525)
5. Zhang MZ*, Didier Merlin. Curcuma Longa-derived nanoparticles reduce colitis and promote intestinal wound repair by inactivating the NF-B pathway. Gastroenterology. 2017;152(5):S567. (Impact factor: 18.392)

6. Zhang MZ*, Yang CH and Didier Merlin. P084 Oral delivery of nanoparticles loaded with ginger active compound, 6-shogaol, attenuates ulcerative colitis and promotes wound healing in a murine model of ulcerative colitis. Gastroenterology. 2018; 154(1):S44. (Impact factor: 18.392)

团队成员：
张明真（研究员/PI，毕业于华中科技大学）
刘 翠（副教授，毕业于武汉大学）
方碧云（助理教授，毕业于华中科技大学）
张玉洁（助理教授，毕业于中国科学院大学生物物理研究所）
屈相龙（助理教授，毕业于同济大学）
杨 梅（2018 级 博士， 毕业于西安交通大学）
颜湘冀（2019 级 博士， 毕业于西安交通大学）
马雅娜（2019 级 博士， 毕业于厦门大学）
高文慧（2019 级 硕士， 毕业于河南师范大学）
张媛媛（2020 级 博士， 毕业于北京大学）
贾真真（2021 级 博士， 西安交通大学硕博连读）
李 蕾（2021 级 在职博士）
程靓靓（2020 级 硕士， 毕业于合肥工业大学）
曹亚蒙（2020 级 硕士， 毕业于华中农业大学）
邓智超（2021 级 硕士， 毕业于郑州大学）
赵媛如（2021 级 硕士， 毕业于云南大学）